Idiopathic Nonspecific Interstitial Pneumonia

Nonspecific interstitial pneumonia (NSIP) pattern is associated with many nonneoplastic disorders such as:^1,2

• Connective tissue disorders
• Drug-induced lung diseases
• Viral infections
• Prior acute lung injury
• Hypersensitivity pneumonitis
• Recurrent organizing pneumonia
• Other rare diseases

A diagnosis of idiopathic NSIP requires exclusion of these other causes.^1,2

Idiopathic NSIP presents as 2 different forms:²

• The fibrotic patten is more commonly diagnosed
• The cellular pattern is rare and has the potential for complete resolution with treatment

1. Primarily affects middle-aged women who were never smokers³
2. The median age of onset is 52 years¹
3. Prognosis for the majority of patients is good with 5- and 10-year survival rates of 82.3% and 73.2%, respectively³
4. NSIP makes up approximately 25% of IIPs⁴